Characterstic Drug Toxicities

Characterstic Drug Toxicities
Agranulocytosis
· Clozapine
Aplastic Anemia
· Chloramphenicol · NSAIDs · Benzene
Atropine-like Side Effects
· Tricyclics
Cardiotoxicity
· Doxorubicin · Daunorubicin
Cartilage Damage in children
· Fluoroquinolones (Ciprofloxacin & Norfloxacin)
Cinchonism
· Quinidine
Coronary Steal Phenomenon
· Dipyridamole
Corneal micro deposits
· Amiodarone
Cough
· ACE Inhibitors
Diabetes Insipidus
· Lithium
Disulfiram-like effect
· Metronidazole · Sulfonylureas (1st generation)
Extrapyramidal Side Effects
· Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)
Fanconi’s Syndrome
· Tetracycline
Fatal Hepatotoxicity (necrosis)
· Valproic Acid · Halothane · Acetaminophen
Gingival Hyperplasia
· Phenytoin
Gray Baby Syndrome
· Chloramphenicol
Gynecomastia
· Cimetidine · Azoles · Spironolactone · Digitalis · Estrogen & testosterone · INH & ethionamide · Clomiphine · Phenytoin · Reserpine & Methyldopa
Hand Foot Syndrome
· 5-Flurouracil (5-FU)
Hemolytic Anemia in G6PD-deficiency
· Sulfonamides · Isoniazid · Aspirin · Ibuprofen · Primaquine
Hemorrhagic Cystitis
· Cyclophosphamide · Ifosamide (Treat by Mesna & Acetylcysteine Bladder Wash)
Hepatitis
· Isoniazid
Hot Flashes, Flushing
· Niacin · Tamoxifen · Ca++ Channel Blockers
Hypertension: Postural
· Prazocin
Hypertension: Rebound
· Clonidine withdrawal
Increased intra cranial tension (­ ICT)
· Amiodarone · Hypervitaminosis A · OCP’s · Tetracycline · Quinolones
Induce CP450
· Barbiturates · Phenytoin · Carbamazepine · Rifampin
Inhibit CP450
· Cimetidine · Erythromycin · Ketoconazole · Isoniazid (INH) [remember CEKI]
Interstitial Nephritis
· Methicillin · NSAIDs (except Aspirin) · Furosemide · Sulfonamides
Milk Alkali Syndrome
· Calcium Carbonate (CaCo3)
Monday Disease
· Nitroglycerin Industrial exposure ® tolerance during week ® loss of tolerance during weekend ® headache, tach, dizziness upon re-exposure
Nephrotoxicity
· Cephaloridine · Gentamycin · Amphotericin
Orange Body Fluids
· Rifampin
Osteoporosis
· Heparin · Corticosteroids
Pancreatitis
· L-Asparginase · Glucocorticoids
Photosensitivity
· Lomefloxacin · Pefloxacin
Positive Coombs’ Test
· Methyldopa
Pulmonary Fibrosis
· Bleomycin · Amiodarone
Rabbit Syndrome (Perioral tremors)
· Phenothiazines
Red Man Syndrome
· Vancomycin (rapid IV)
Severe HTN with Tyramine
· MAOIs
SLE- Drug Induced[Anti Histone Antibody Characteristic of this]
· Chloropromazine · Hydralazine · Isoniazid · Methyldopa · Procainamide · Quinidine [ remember CHIMP -Q]
Tardive Dyskinesia
· Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)
Tinnitus
· Aspirin · Quinidine
Torsades de Pontis
· Terfanadine